Speaker: Nicole I Wolf, Ass. Professor, Department of Child Neurology, Center for Childhood White Matter Diseases, Emma Children's Hospital, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, and Amsterdam Neuroscience, (Netherlands)

Learning Objectives: (1) Explaining the hereditary causes, disease characteristics, signs and symptoms of MLD (2) Exploring the impact on the central nervous system, peripheral nervous system and motor function (3) Reviewing how early-onset clinical manifestations are often overlooked or confused with other conditions (4) Understanding the early signs of MLD that every pediatricians should look for that should trigger an early referral

Metachromatic Leukodystrophy (MLD) is a rare hereditary disease characterized by the accumulation of fats called sulfatides. This causes the destruction of the protective fatty layer (myelin sheath) surrounding the nerves in both the central nervous system and the peripheral nervous system, ultimately affecting intellectual and motor function. Early-onset clinical manifestations are often overlooked or confused with other conditions causing confusion among non-trained HCPs at first contact, resulting in misdiagnosis, wrong referral routes and delays in the early start of treatment. Delays in starting treatment have significant consequences on the conditions’ development, and the patient’s health and quality of life. This delay in referral and treatment must be overcome.

The webinar is free-to-view and a certificate of attendance will be provided by the EIP Institute for those who attend online or watch the video after the webinar is organised.