THE SPOT THE EARLY SIGNS OF MLD COURSE PROGRAM

Metachromatic Leukodystrophy (MLD) is a rare hereditary disease characterized by the accumulation of fats called sulfatides. This causes the destruction of the protective fatty layer (myelin sheath) surrounding the nerves in both the central nervous system and the peripheral nervous system, ultimately affecting intellectual and motor function. Early-onset clinical manifestations are often overlooked or confused with other conditions causing confusion among non-trained HCPs at first contact, resulting in misdiagnosis, wrong referral routes and delays in the early start of treatment. Delays in starting treatment have significant consequences on the conditions’ development, and the patient’s health and quality of life. This delay in referral and treatment must be overcome. 

LEARNING OBJECTIVES

✓ Introduction to Microglia - a specialised population of macrophages-like cells in the CNS           

✓ Reviewing microglia’s involvement in promoting or limiting the pathogenesis of diseases    

✓ Exploring the potential for the management and treatments of neurometabolic disorders